The skull is like a protective shield for the brain tissue, it is tough and strong, but because of factors such as traumatic brain injury and craniosynostosis, craniotomy is performed, and as a result, the skull may be damaged. After skull defect, the appearance is affected, and the cranial cavity environment is also destroyed, which will inevitably bring more other effects on the body, and in serious cases, there is even a risk of life. Cranial defect is to be paid attention to, the defective part generally will not grow well by itself, and will collapse and deformation, etc. If the secondary collision occurs accidentally, the consequences are more serious, so the cranial defect should go to the hospital to do cranial repair surgery in time. But there is one point to note, the material for skull repair surgery is really the most important, choosing a good material can greatly improve the success rate of surgery, and also can better avoid some post-operative complications. At present, the main clinical skull repair material is titanium mesh material and new polyetheretherketone peek material, what is the difference between ordinary titanium steel and new material for skull repair? Titanium mesh material is a kind of metal material, which is used for overlay surgery, patients may have cutting pain, and titanium mesh material is not too ideal in terms of histocompatibility and heat insulation, etc., and postoperative problems such as rejection and infection may also occur, in addition to affecting postoperative medical examination, etc. But the new peek material is a very safe polymer material, using the embedded surgery, it is very close to the human skull in terms of tissue compatibility, stability, hardness, etc., and can be personalized three-dimensional shaping energy, the post-operative effect is very good, so now the use of peek material for skull repair surgery has become a new trend. Here we have successfully applied peek material in the treatment of skull defects and skull repair surgery earlier, and the team has deeply researched and practiced, and also introduced the concept of aesthetic plastic surgery in the surgery, the post-operative effect is more natural and beautiful, and the patients and their families are very satisfied.