Gallstone disease is often referred to as the “5 F’s”: Fat, Forty, Female, Fertility, and Family. The more “F’s” you have, the greater the chance of developing gallstones. This is because estrogen causes cholesterol to collect more in the bile, and middle-aged and older women are prone to stone formation because of the decrease in estrogen and metabolic level in their bodies. The symptoms of gallstones are pain in the upper abdomen that radiates to the shoulders and back, and low fever, nausea, vomiting, chills, profuse sweating and even jaundice. These symptoms are non-specific and similar to those of gastrointestinal and liver diseases, so patients may delay the diagnosis on their own by mistaking them for gastrointestinal diseases or liver diseases. Therefore, patients who are diagnosed with cholelithiasis should be treated as early as possible, with regular reviews and a combination of prevention and treatment. Surgery is the first choice for treatment, and the current minimally invasive laparoscopic surgical treatment allows patients to obtain the maximum therapeutic benefit.