Tacrolimus capsules and Irbesartan can be taken together. Tacrolimus capsule is an immunosuppressive macrolide, Irbesartan is an antihypertensive drug, taken together will not cause adverse reactions or toxicity, there is no medical evidence-based proof that the two drugs taken together will cause contraindications such as the occurrence of adverse reactions. Tacrolimus capsule can prevent a series of lymphokine gene transcription, from can play the role of rejection, clinically applicable to liver transplantation, kidney transplantation and so on. It can cause hypertension, visual disorders, migraine, liver function abnormalities, hypokalemia, gastrointestinal dysfunction and other adverse reactions. Irbesartan can inhibit vasoconstriction and aldosterone release, producing a hypotensive effect. It is suitable for hypertension, type II diabetic nephropathy combined with hypertension. It can cause postural hypotension, skeletal muscle pain, hyperkalemia and other adverse reactions. Both of the above drugs are prescription drugs, if you need to use the drug, you should use it under the guidance of a doctor to avoid causing adverse reactions.