How long the patients with middle and late stage of intestinal adenocarcinoma live can be evaluated by five-year survival rate, generally after active treatment, the five-year survival rate is about 10%~70%, and the specifics need to be judged with the patient’s condition. Intestinal adenocarcinoma is a common malignant tumor caused by heredity, gene mutation, bad dietary habits and other factors. Intermediate and late-stage patients can be treated by surgery, radiotherapy, targeted therapy, immunotherapy and other therapies. After active treatment, the five-year survival rate of patients with middle and late stage of intestinal adenocarcinoma is about 10%~70%. Clinical practice often does not take the number of years of survival as an indicator for judging the prognosis. In addition to the staging, the patient’s physical quality, treatment effect and other factors are also related to the survival period. If the physical quality is good and the treatment effect is ideal, the survival period is longer, otherwise, the survival period is lower. After surgery, patients should pay attention to regular review as prescribed by the doctor, maintain good habits in daily life, and exercise appropriately, etc., which can effectively prolong the survival period of patients and reduce the recurrence rate of the disease.