The term “Hashimoto” generally refers to Hashimoto’s thyroiditis. Thyroglobulin antibodies are a common autoantibody found in the serum of patients with autoimmune thyroid disease. High thyroglobulin antibodies in patients with Hashimoto’s thyroiditis can be treated with medication or surgery. People with only goiter and no hypothyroidism usually do not need treatment. Clinical treatment focuses on symptoms of hypothyroidism and goiter compression. Levothyroxine replacement therapy is given primarily for clinical or subclinical hypothyroidism. Glucocorticoid therapy is given for rapid enlargement of the thyroid gland with localized pain or compression symptoms. Surgery may be considered if compression symptoms are obvious and not relieved by medication, but the probability of postoperative hypothyroidism is high. Patients with Hashimoto’s thyroiditis who have high thyroglobulin antibodies are recommended to undergo standardized treatment under the guidance of a doctor.