It is wrong to say that rabies vaccination is not necessary beyond 72 hours. In fact, the earlier the vaccination, the higher the success rate of prevention, and the later the vaccination, the higher the risk. Rabies virus is a neurotropic virus that mainly affects the central nervous system. Vaccination is effective until the virus enters the nervous system, but the rate at which rabies virus invades the human central nervous system and proliferates varies greatly among individuals. According to currently implemented guidelines and treatment protocols, formal follow-up treatment should be performed as soon as possible after Grade II or higher exposure, and the body begins to produce antibodies approximately 7 d after rabies vaccination, and effective protection can be reached in about 14 d. Before the vaccine takes effect, for grade III exposure to rabies virus, the wound should be thoroughly cleaned and the surrounding infiltrate injected with a passive immunization agent, i.e., human rabies immunoglobulin or equine-derived anti-rabies serum, at the same time as the vaccine is administered to prevent the virus from entering the neural tissue for rapid protection. In addition, pre-exposure prophylactic rabies vaccination is recommended for all individuals who have been continuously and frequently exposed to rabies virus in a hazardous environment. Therefore, after an exposure has occurred, vaccination is effective until the virus enters the nervous system; there is no minimum deadline, and protection can be enhanced with passive immunization preparations until the vaccine takes effect; there is absolutely no such thing as no need for rabies vaccination beyond 72 hours.