Dogs are the animals with the highest risk of spreading rabies, and more than 95% of human rabies infections are transmitted by dogs. However, it is not certain that a dog bite will result in rabies, in addition to whether the dog is contagious, it also depends on how the person is handled after exposure. The probability of rabies in a vaccinated dog is very low, and a dog that has been vaccinated for two consecutive years can be considered basically not to change rabies again, and it is not possible to infect people with rabies, but given the differences in the quality of canine vaccines in different regions, caution is still needed for canine bites, and it is best to vaccinate first and then take the 10-day observation method at the same time, if the dog is fine after 10 days, the person is completely excluded from the risk. The rest of the vaccine can be given without vaccination. If the dog shows signs of rabies within 10 days, the person will need emergency vaccination and, in cases of severe exposure, rabies immunoglobulin. If there is no guarantee that the dog is healthy, it is the bite that should be vaccinated. Rabies exposure can be divided into three levels according to the depth of the wound and exposure: intact skin contact with animals and animal secretions is a class I exposure. Class II exposures are scratches, bites or wounds that have not yet healed and come into contact with animals and secretions without obvious bleeding. Class II exposures have the potential for infection and should be treated immediately with rabies vaccination. Scratches and bites with obvious bleeding as well as fresh wounds or mucous membranes in contact with animals and secretions are Class III exposures. Those judged to have a Class III exposure are at high risk of infection and should have their wounds treated immediately and given rabies immunoglobulin followed by rabies vaccination. After determining the level of exposure, the physician at the rabies prophylaxis clinic is required to immediately treat the wound as needed; after informing the exposed person of the danger of rabies and the disposal measures that should be taken and obtaining informed consent, the appropriate disposal measures are taken. Therefore, in theory, people who have been bitten by a vaccinated dog do not need to get the shot again, but because in reality it is difficult to ensure that all animals are vaccinated and that animal vaccines have achieved protective effect, human-initiated rabies vaccination is the most effective means of prevention.