A variety of clinical lesions can lead to gastrocnemius pain, and gastrocnemius lesions mainly include infection, trauma, nerve injury, and lower limb thrombosis. It is recommended to seek medical attention for the appropriate identification after the appearance of symptoms, so as not to delay the condition and lead to adverse consequences. 1, infection: if a local infection of the gastrocnemius muscle occurs, severe pain may occur, which may also manifest as local gastrocnemius skin redness and swelling, fever and severe pain and other symptoms. Generally after active antiviral treatment lesions can be healed; 2, trauma: gastrocnemius muscle suffered trauma or for other reasons, tibiofibular fracture, strain and other causes of injury, can also appear painful feeling. The pain caused by the fracture is more intense and generally accompanied by dysfunction, which needs to be treated by fixed surgery; 3, nerve injury: damage to the tibial nerve that governs the gastrocnemius muscle can lead to numbness, pain and other symptoms of the gastrocnemius muscle, generally longer recovery time from nerve damage, and in severe cases, the ability to move may be lost; 4, lower limb thrombosis: in some patients, due to thick blood, long-term inactivity, etc., can occur in the lower limb venous thrombosis, the occurrence of lower limb Patients with venous thrombosis have relatively poor blood circulation, which can be manifested as local muscle swelling and pain in the lower limbs. If the swelling is more serious, the local skin can also show cyanotic changes; 5, calcium deficiency: muscle twitching symptoms can occur, which leads to gastrocnemius pain symptoms, after taking calcium treatment as prescribed by the doctor, the symptoms can be relieved. In conclusion, there are more causes of gastrocnemius pain, and the specific cause needs to be further clarified by the doctor combined with the patient’s clinical examination results, such as blood routine, blood biochemistry, tibiofibular x-ray and clinical symptoms.