Pre-leukemia symptoms: 1. Patients with leukemia may have early onset of anemia and may often feel weak and fatigued, and have pallor, palpitations, and even lower limb edema. In this case, blood tests must be performed as early as possible.2. Patients may develop leukemic infiltration of bone and periosteum, which causes pain in the bones, either as diffuse pain in the limbs and back, or confined to joint pain, and can also lead to difficulty in movement, and even in 1/3 of patients, can be accompanied by pressure pain in the sternum.3. Local enlargement of lymph nodes and liver and spleen may occur.4. Patients may develop skin , gum, and nasal bleeding, which even become common, while women may experience excessive menstruation. For these symptoms, early attention must be paid.