Creatinine 401umol/L can be treated with some detoxification drugs, such as medicinal charcoal tablets, Haikun Kidney Hi capsules, urinary toxicity clear granules, etc. In addition, we should actively search for the cause of the disease and treat it from the cause. The normal value of creatinine is below 110umol/L, if it exceeds 110umol/L it indicates renal failure. From here, we can see that creatinine 401umol/L is far more than 110umol/L. At this time, we need to apply detoxification drugs to help detoxify the kidneys, and the more commonly used detoxification drugs have been mentioned above. Of course, the main thing is to find the cause of the disease and deal with it from the cause. Chronic renal failure is divided into chronic and acute, the more common causes of chronic renal failure are diabetic nephropathy, chronic glomerulonephritis, purpura nephritis, lupus nephritis, obstructive nephropathy and so on. The causes of these diseases are different, so the treatment methods are also different, for example, diabetic nephropathy is treated by lowering sugar, while purpura nephritis needs to be treated with anti-allergic drugs, lupus nephritis needs to be treated with hormones and immunosuppressive drugs, etc. The more common causes of acute renal failure are massive consumption of nephrotoxic drugs and acute glomerulonephritis. The former requires symptomatic treatment and hemodialysis if necessary, while the latter requires treatment with hormones combined with immunosuppressants and hemodialysis.