The size of lymph nodes is 2.5cm is not normal, because normal lymph nodes are around 1cm or less than 1cm. lymph node enlargement can be seen in many reasons, malignant tumors have regional lymph node metastasis, because the most common way of metastasis of tumors include lymphatic metastasis, hematogenous metastasis, and some patients are caused by direct invasion, if ultrasound finds lesions larger than 2.5cm, further surgical biopsy should be performed. If the lesion is found to be larger than 2.5 cm by ultrasound, further surgical excisional biopsy should be performed to clarify the pathological staging and to guide the next clinical treatment. In many patients, the pathology can be clarified by local biopsy, and effective treatment should be carried out, which can prolong the survival time of patients to some extent. For patients with malignant tumors, late stage may also show fusion, hyperplasia and enlargement of lymph nodes, which can be treated by general treatment to minimize the patient’s pain. In case of severe pain, targeted pain relief treatment can be given if necessary.