Hepatitis B 1, 4 and 5 positive, i.e. “minor triple positive”, suggests that the test taker is infected with the hepatitis B virus, the transmission rate is relatively low, but also for the liver is damaged. The severity of minor triple positive cannot be judged only on the basis of the results of hepatitis B 5, but also on the basis of the results of liver function, HBV DNA, liver ultrasound and other tests. The regression of chronic HBV infection varies, from an inactive carrier state to progression to cirrhosis, hepatic dysfunction, hepatocellular carcinoma, extrahepatic manifestations or even death. The prognosis seems to vary depending on the clinical situation. If the patient’s test result is positive for items 1, 4 and 5, it is recommended to improve other related examinations in time and decide whether to initiate antiviral therapy under the comprehensive assessment of the doctor, so as to slow down the progression of hepatitis B disease and prolong life.