High-risk HPV-DNA positivity may be caused by infection with the virus. This can be caused by many things, such as sexual activity, low immune function, and age. 1. Sexual activity. The first time you have intercourse at too young an age, or take no measures to have intercourse, or have intercourse with multiple sexual partners, may cause HPV-positive signs to occur. 2. When the body is weaker and resistance is lowered, it may cause high-risk HPV-DNA positivity to occur. 3. Mostly occurs in women who are already married or close to the childbearing stage, generally between the ages of 32-45, this age group may also induce the occurrence of high-risk HPV positive.