There are many reasons for the lack of energy and fatigue, such as sleep deprivation at night and other physiological reasons, but also by hypothyroidism, sleep disorders, neurasthenia, anemia and other pathological reasons. Different causes, different treatments and medications, need to use drugs under the guidance of a doctor, should avoid self-medication to prevent delays. 1. If it is due to stay up late at night, sleep at night, such as lack of sleep caused by the lack of energy and fatigue want to sleep, at this time, generally no treatment, need to pay attention to adjust the routine of work and rest, go to bed on time, avoid staying up late to ensure that adequate sleep, generally after adjustment can be returned to normal on their own. 2. If it is due to hypothyroidism, you can take levothyroxine for treatment. 3. If it is due to sleep disorder, you can use benzodiazepines, non-benzodiazepines and melatonin agonists for treatment. 4. If it is caused by neurasthenia, you can use antidepressants, such as fluoxetine, paroxetine, fluvoxamine, sertraline and so on. 5. If iron deficiency anemia caused by a lack of energy and want to sleep, you can take iron succinate tablets and other drugs. If you can’t get any relief from sleep, you should go to the hospital in time to find out the cause of the disease and follow the doctor’s instructions for treatment.