I. Drug therapy: 1. Injectable drug therapy (1) haloperidol (2) chlorpromazine static (3) clonidine intramuscular injection therapy 2. Oral drug therapy: (1) lithium carbonate, generally should be used under the monitoring of blood lithium concentration, otherwise lithium toxicity is easy to occur. (2) chlorpromazine, clozapine, should be regularly checked blood routine, liver and kidney function and electrocardiogram. (3) Clonidine, has a strong control of psychomotor excitation, anti-manic effect is significantly better than other neural blockers and the side effects are small. (4) Sodium phenytoin (5) Sodium valproate (6) Carbamazepine (7) Quetiapine, aripiprazole, risperidone, olanzapine, lamotrigine, topiramate, gabapentin, etc. (2) Electroconvulsive treatment (3) Maintenance treatment Although manic symptoms are easily controlled, they are also easy to relapse, so maintenance treatment for a certain period of time is required. For the first-episode patients, lithium treatment should be maintained for at least 6 months after the recovery of mania. For those who have relapses every year, lithium salt should be used to maintain for a long time, and at this time, extended-release agents are available. Anti-relapse treatment Mania has the characteristics of recurrent attacks, and anti-relapse treatment is often required. 1, the first mania patients, cure maintenance for a period of time can gradually stop, no anti-relapse treatment. However, if the symptoms of recurrence are found such as reduced sleep, more talking and more activities, treatment should be resumed immediately. 2.Patients with recurrent mania, anti-relapse treatment after cure should be carried out according to the law of relapse. ① If there is one seizure in a year, see what season the seizure is often in, and take the medicine before the arrival of the season. If there is no regularity in seizures within a year, medication should be taken year-round. ② For those who have one recurrence in more than two years, you can start taking medication sometime in the year of recurrence. ③Anti-relapse treatment for those without certain seizure regularity is a tricky problem, but anti-relapse treatment is not required, but it should be observed and medication should be administered urgently if there is a hint of relapse. ④The anti-relapse drug has been recognized as lithium carbonate, in addition, small and medium doses of antipsychotics are often used as anti-relapse drugs for mania, carbamazepine or sodium valproate can replace lithium carbonate as anti-relapse drugs for mania. Fifth, to prevent turning: some manic patients will turn into depressive episodes, and need to be closely observed.