Mothers with bipolar sons have a certain genetic chance, but not necessarily have mania. Mania, that is, bipolar disorder, the onset of the causative factors is very complex, in addition to genetic factors, there are central neurotransmitter function and metabolic abnormalities, personality traits, psychosocial factors and so on. They are as follows: 1. Genetic factors: biological relatives have a significantly increased risk of the disease, and the closer the blood relationship, the higher the prevalence rate. 2. Abnormal function and metabolism of central neurotransmitters: e.g. dysfunction of the norepinephrine system, dopamine hypothesis, dysfunction of the 5-hydroxytryptamine system, and neuroendocrine dysfunction. 3. Character traits: introverted people can not express their true thoughts and feelings, such as often in stressful situations, when the emotions in the heart can not be released, the chances of suffering from mania are also higher. 4. Psychosocial factors: stressful life events and mood disorders, common negative life events, such as widowhood, divorce, marital disharmony, unemployment, serious physical illness, or sudden death can induce mania. Attention can be shifted, physical exercise increased, and unreasonable study and work styles can be adjusted to improve the state of tension.