Due to the influence of disease factors such as pediatric rabies, mania alternating with lethargy and cranky abnormality during attacks occur. Rabies is a zoonotic acute infectious disease of the central nervous system caused by rabies virus. What are the auxiliary tests for alternating mania and lethargy? 1, peripheral blood picture and cerebrospinal fluid: total white blood cell count is mildly to moderately elevated, central granulocytes account for 80% of the cerebrospinal fluid cell count and protein may be slightly increased, sugar and chloride are normal. 2, pathogenic examination: brain tissue within the basal vesicle test; patient oral secretions, cerebrospinal fluid and brain tissue inoculation mouse brain isolated virus, rabies virus nucleic acid detection, etc. 3, virus antibody detection: fluorescence immunization method to check antibody serological antibody examination. Early misdiagnosis is easy, even in children and those with unclear bite history. Patients who are already in the attack stage can be initially diagnosed based on the history of the bite and the prominent clinical manifestations. A positive immunofluorescence test will establish the diagnosis. Quiet bed rest, prevention of all sound, light, wind and other stimuli, large intravenous cannula for high nutrition therapy, medical staff must wear masks and gloves, wearing isolation clothing. The patient’s secretions, excretions and their pollutants must be strictly disinfected. Actively do symptomatic treatment to prevent and control various complications. Trauma deep and wide, serious or occur in the head, face, neck, hands, etc., at the same time the bite animal really has the possibility of rabies, should be immediately injected rabies serum, the serum contains high-valence anti-rabies immunoglobulin, can directly neutralize rabies virus, should be applied early, immediately after the injury, then a week after the injury almost invalid.