The effects of disease factors such as pediatric rabies cause the appearance of mania alternating with lethargy and abnormal crankiness during attacks. Rabies is a zoonotic acute infectious disease of the central nervous system caused by the rabies virus. The main clinical manifestations are characteristic mania, fear and agitation, fear of wind and water, salivation and pharyngeal muscle spasms, and ultimately life-threatening paralysis. What is the diet related to alternating mania and lethargy that needs attention? Avoid alcohol and strong tea, and do not eat spicy food. Make sure your body is healthy and don’t work too hard. The key is alcohol, which has a strengthening effect on all medicines and can affect the effect of vaccine measurement. Secondly, if you are weak, your own antibody production becomes less strong, and you will be defeated by the “safe virus” brought by the vaccine if you are not careful. It is now believed that the local presence of the virus is not the only factor leading to differences in clinical manifestations; humoral and cell-mediated immunity are protective in the early stages, but when the virus enters the nerve cells in large numbers, then there is a relationship between immune-mediated damage and morbidity, and death is delayed in immunosuppressed mice after rabies virus inoculation and accelerated after passive input of immune serum or immune cells. In human rabies, those whose lymphocytes are positive for rabies virus cell proliferation tend to be manic and die more quickly.