OBJECTIVE: To investigate the clinical efficacy of laparoscopic excision of adenomyotic lesions and uterine artery blockade in the treatment of adenomyosis and the postoperative changes in serum CA125 and sex hormones. METHODS: Laparoscopic excision of adenomyotic lesions and uterine artery block were performed in 98 patients with adenomyosis, and other pelvic lesions were also treated intraoperatively; the degree of dysmenorrhea, menstrual volume, hemoglobin, uterine volume, blood CA125 and sex hormone levels were monitored after surgery. Results: All 98 cases were operated laparoscopically, and all of them were pathologically confirmed as adenomyosis after surgery, with an average follow-up of 26.3±8.6 months. Two patients had postoperative pedestrian abortion for unplanned pregnancy. CONCLUSION: Laparoscopic excision of adenomyotic lesions and uterine artery blockade is safe and effective in the treatment of adenomyosis, and can be a treatment option for young patients with a desire to preserve the uterus.