Menopause at the age of 40 is premature ovarian failure, in which case patients are advised to intervene, and how to do so depends on the patient’s specific situation. If the patient’s sex hormone count and ovarian function decline are not obvious, treatment can be done by taking tonics or kidney tonics such as Kuntai capsule, deer fetus cream and Erxian Tang. If the treatment effect is not good or the decline of ovarian function is obvious, you can choose estrogen and progesterone compound for treatment, such as the most commonly used Clomid, which can be taken for a long time, but before taking it, you need to conduct a comprehensive physical examination to exclude serious liver and kidney function damage or thrombosis and other diseases, and you also need to conduct regular physical examination during the first three months to six months of use. Generally, if no special condition occurs within six months of application, it should be safe to apply for a long time.