Children can apply quadruple therapy, which is generally used as a drug treatment program for chronic gastritis or peptic ulcer, and the application of this program can effectively treat the disease. Chronic gastritis and peptic ulcer in children can be caused by various factors such as Helicobacter pylori infection, genetics or psycho-neurological factors, etc. Children may have recurrent abdominal pain and many different manifestations. At present, the majority of advocate the use of combination drugs, generally more triple therapy (such as with omeprazole + clarithromycin + amoxicillin), the failure of the choice of quadruple therapy (such as omeprazole + amoxicillin + metronidazole + bismuth citrate) for the treatment. Children with gastritis or peptic ulcer, need to consult a doctor in time, active treatment, and pay attention to regular review, pay attention to quantitative diet in life, avoid eating stimulating food or drugs that damage the gastric mucosa. The above drugs should be used according to the doctor’s prescription.