The National Cholesterol Education Program recommends that all patients with coronary artery disease should have LDL cholesterol, HDL cholesterol, and triglyceride levels measured; all patients with coronary artery disease with a combination of low HDL cholesterol and high triglycerides should have their lifestyle changed. Unless triglycerides are ≥500 mg/dl (at which point fibrates should be preferred to lower triglycerides and prevent pancreatitis), the primary goal of lipid-regulating therapy in such patients remains LDL cholesterol, which should first be lowered to levels below 100 mg/dl or lower, while raising HDL cholesterol to above 40 mg/dl if possible. The World Health Organization guidelines for cardiovascular disease prevention (2007) state that long-term or even lifelong statin therapy is recommended for all patients with coronary artery disease, and that the ideal target values for total cholesterol should be <155 mg/dl and LDL cholesterol <80 mg/dl.