The patient is 61 years old, and he was injured by a small stone on the bottom of his foot, which got worse day by day for a month, and finally left a deep hole on the bottom of his foot, and blood and water always flowed out. But I have been taking medication and injections, why can’t I see any effect? What should I do? In this case, there is no doubt that it is an infection, the healthy tissue is gradually eroded, the tissue fluid is broken and then oozes out, the fluid flow is either purulent secretion, or mixed with blood. In this case, if the pain and swelling are severe, it is still necessary to do an examination to detect whether the bone is infected, such as an MRI, to avoid the development of osteomyelitis. Why is this condition difficult to control? Human factors such as improper care, not keeping it clean, not going to treatment or improper treatment; non-human factors such as the patient’s age, high blood sugar, living alone, declining physical function, lack of exercise, suffering from cardiovascular disease, etc. However, the most critical issue is still the control of infection. Control of infection should not be like scratching an itch, such as eating some anti-inflammatory drugs, smear some anti-inflammatory water, anti-inflammatory injection, these simply can not solve the problem. Because many diabetic foot patients are not what they seem to be, some patients do not look serious, just a hole, but underneath the hole is a radical change, so serious that people can not believe it. Therefore, patients like the one mentioned at the beginning and those with similar conditions must pay attention to it. Do not look at just a small hole, which does not even have much impact on your life, maybe it is already very serious inside. In this case, you need to promptly go to the local professional treatment of diabetic wounds specialist or regular hospital, open the wound trauma situation, clean out the necrotic tissue. Especially infected necrotic skin, muscle, blood vessels and bone, which are hotbeds of germs, on which live a large number of flora, conditions suitable for reproduction speed. The infection will be much better controlled after cleaning, but do not think of more cleaning to clear all the germs together, it is impossible and totally unnecessary in our current medical condition. We only need to control the germs to a certain extent and use the appropriate method to control the infection. Of course, besides controlling the infection, the most important thing is to promote the growth of the wound and to promote the proliferation of healthy tissue to heal the wound. There are quite a few treatments involved, such as improving circulation in the lower extremities, nourishing the nerves, improving the patient’s own immunity, and so on. It is advisable to have these done in a department specializing in the treatment of diabetic foot, so as not to add to the wound by improper treatment.