Incisional pain after open-heart surgery is very intense, and the consumption of anesthetics for pain relief after open-heart surgery is the largest of all surgical procedures. Due to the severe pain, it restricts the patient’s deep breathing and coughing up sputum, which often leads to complications such as pulmonary atelectasis and bronchopneumonia. Therefore, the effect of pain relief after open-heart surgery has a greater impact on the postoperative patient’s recovery. For a long time, clinicians have been seeking a safe and effective method of pain relief, but the use of other methods has been limited in clinical practice because of their potential disadvantages. The pain-relieving and anti-inflammatory effects of cryopreservation are well known, and in recent years, our department has achieved satisfactory results in preventing chest pain after open-heart surgery through intercostal nerve cryopreservation. The advantages of intercostal nerve cryosurgery to prevent chest pain after open heart surgery: 1, freezing is a targeted, reversible physical therapy. 2, safe and reliable. 3.Significant efficacy and few postoperative morbidities. 4.Simple operation and easy implementation. 5, shorten the patient’s hospitalization time. Complications after intercostal nerve cryosurgery: 1. Numbness and stiffness of the chest wall. 2.Sense of distension of the abdominal wall on the same side of the operation. The main reason is the loss of innervation of the chest wall skin after nerve necrosis, but these discomforts will gradually disappear with the regeneration of the nerve.