Patients with chronic granulocytic leukemia usually have abnormally high leukocytes, which can be as high as 100×10^9/L or more, and some patients are seen clinically to have leukocytes as high as 400×10^9/L or more. Patients with this abnormally high leukocyte count have a high tumor load and the body will develop an abnormally enlarged spleen, or giant spleen, along with systemic symptoms such as fever, wasting, and night sweats. Patients often have a series of manifestations such as abdominal distension, poor eating, nausea after eating due to the presence of giant spleen. Once the diagnosis of chronic granulocytic leukemia is made, oral tyrosine kinase inhibitors are required, and after the oral tyrosine kinase inhibitors are effective, the patient’s giant spleen will gradually shrink.