Stomach cancer is a common malignant tumor in clinical practice, and its incidence rate has been occupying the top of common tumors. For early gastric cancer, people know that it should be actively treated by surgery. However, due to the onset of gastric cancer and the insidious nature of early gastric cancer, in clinical practice, gastric cancer is often found in the middle and late stages, losing the opportunity of radical surgery. And because the prognosis of advanced gastric cancer is relatively poor, many patients give up active treatment. Although modern medicine still has no suitable means to cure advanced gastric cancer, the aim of treatment for advanced gastric cancer is to prolong life and improve life quality. And practice proves that including palliative surgery, best supportive care, chemotherapy, radiotherapy, Chinese medicine treatment, clinical trials and other means can significantly increase the 1-year survival rate of patients and improve the quality of survival. Clinically, there are many patients with advanced gastric cancer surviving for 3 years, 5 years or even long term with tumor after aggressive palliative treatment. What’s more, with the development of biomedicine in recent years, various anti-tumor drugs and new technologies are being introduced continuously, and the efficiency of advanced cancer treatment is also improving. Therefore, patients with advanced gastric cancer should not give up lightly, but should adopt a positive and optimistic attitude towards the treatment of advanced tumors.