If you are unfortunate enough to have multiple tumors in your liver on examination and have elevated alpha fetoprotein, a clinical diagnosis of liver cancer has been made. In such a devastating situation, what would be your choice for your treatment? Recently, I have admitted two such patients. These two patients were diagnosed with advanced liver cancer in two tertiary hospitals in the city, and both of them had already undergone interventional treatment twice before they were referred to me for treatment. When I saw the patients, the patients were already “gray” mentally. Although both of them were smiling, their desire for life could still be seen. One of the two patients had 5 tumors in the liver, one large one in the left outer lobe and 4 small ones in the CT film. The other had 4 tumors, 3 on the surface of the liver and the other deeper in the caudate lobe. Most fortunately, no portal vein carcinoma thrombus was found in either one. Multinodular hepatocellular carcinoma can be divided into multicentric growth and monocentric growth due to their different biological patterns, which are basically divided in half. For tumors with multicentric growth, better treatment results can be achieved if active measures are taken. For both patients, we adopted the surgical resection method and used minimally invasive treatment for the tumors that were difficult to be resected. Both patients were clinically cured. Now the patient has been postoperative for six months, and all tumor indexes are back to normal, and there are no new lesions. If you have this kind of disease, don’t think that you have reached the advanced stage and treat conservatively. You should know that you still have a hope of cure.