Expired Keserol can not be used for clinical treatment. The main ingredients of Keserol are magnesium sulfate and mannitol, which are commonly used in the clinic as laxative drugs, belonging to the external use of drugs, which are more effective for the treatment of constipation, but should be avoided for a long period of time, which may cause irritation to the intestinal wall and interfere with the normal bowel habits. However, the use of expired Corkscrew may affect the therapeutic effect, mostly because the composition of expired Corkscrew may be deteriorated, and can not play the role of softening the stool. In addition, after the expiration date, the ingredients of Corkscrew have changed, and some patients may also experience local allergies, pain, infection and other symptoms. So to be on the safe side, expired corkscrew is not recommended. Drugs need to pay more attention to the shelf life, but also need to pay more attention to the way the drug is stored, improper storage will also affect the quality of the drug, thus affecting the effect.