1, direct damage to the intestinal mucosa. Long-term constipation without treatment may lead to intestinal wall damage and hemorrhoids, where the accumulation of toxins may also cause cytopathy, leading to colon cancer. 2, induced heart attack and cerebrovascular accidents. Senior patients with cardiovascular disease, excessive intra-abdominal pressure during defecation, may cause atherosclerosis of the coronary arteries within the plaque off, blocking the coronary arteries cause acute myocardial infarction; can also cause a sudden increase in blood pressure in a short time, inducing cerebral hemorrhage and subarachnoid hemorrhage. 3, cause rupture of the esophagogastric fundus varices bleeding. Various causes of cirrhotic esophagogastric fundic varices may induce rupture of varices causing hemorrhage due to short term increase in portal pressure when forceful stooling. 4, induced pneumothorax. Excessive intra-abdominal pressure when defecating can induce pneumothorax in patients with long-term obstructive emphysema and pulmonary alveoli, causing acute respiratory distress. 5, the formation of ventral hernia. Constipation, due to excessive bowel movements, intra-abdominal pressure suddenly increased, intra-abdominal organs through the abdominal wall weakness to the body surface protrusion, may form a ventral hernia. 6, causing gastroesophageal reflux disease occurs. Long-term need to force defecation may cause gastroesophageal reflux disease. 7, cause sexual life disorders. This is due to each prolonged forceful defecation, so that rectal fatigue, anal contraction is too tight and spasmodic contraction of the pelvic floor, resulting in non-ejaculation or loss of libido, sexual life without orgasm, etc.. 8, affect the beauty. Constipation patients due to prolonged retention of fecal blocks in the intestine, abnormal fermentation, corruption can produce a large number of harmful toxins, prone to acne, facial pigmentation, rashes, etc.. 9, easy to induce gynecological diseases. Constipation can easily make women suffer from dysmenorrhea, vaginal cramps, and production of urinary retention, urinary tract infections and other symptoms. Long-term constipation can increase the risk of breast cancer in women. 10, leading to obesity. Toxins lead to edema of the colon, the lower body blood circulation slowed down, easy to form a pear-shaped body as well as fat stomach.