The course of chronic hepatitis B is often long, so in addition to regular and reasonable medication, patients should also pay attention to regular follow-up examinations. This is a necessary procedure to understand the effect of treatment and changes in the condition, so it should not be ignored. The items to be reviewed should be comprehensive and the results should be accurate, so it is best for patients to go to a regular hospital with conditions for review. The main items of re-examination include: 1, liver function series of indicators glutamic aminotransferase (ALT), glutamic aminotransferase (AST), cholinesterase (CHE), transpeptidase (GGT), albumin (ALB), globulin (GLO), total serum bilirubin (TBIL), direct bilirubin (DBIL), prothrombin activity (PA) and so on. Based on the above indicators, we can determine what stage the disease is in, whether it is mild or severe. 2. Blood count including white blood cells, red blood cells, hematocrit, platelets and so on. Once the disease enters the stage of cirrhosis, the change of blood picture can often indicate the severity of the disease. For example, in the early stage of cirrhosis, platelets are mildly reduced; in the middle and late stage of cirrhosis, hypersplenism, the whole blood is decreased; if the hematocrit is reduced, pay attention to whether there is gastrointestinal bleeding phenomenon. 3.AFP (alpha-fetoprotein) Generally, hepatitis AFP is rarely elevated, and even if it is, it rarely exceeds 200 ng. However, in liver cancer, AFP is often greater than 400 ng. If the AFP continues to not drop and remains above 400 ng, it is important to pay attention to the possibility of liver cancer. 4.B ultrasound Through regular ultrasound examination, we can understand the size and shape of liver, echogenicity, inner diameter of portal vein, thickness of spleen and the presence of ascites, which can determine whether the condition is changing towards cirrhosis or whether there are occupying lesions occurring. 5.Gastroscopy When it is not possible to determine whether there is cirrhosis based on laboratory results, gastroscopy can be performed to understand the esophageal mucosa and periesophageal varices and gastric fundic varices. If varices exist, it means cirrhosis has occurred. 6.Liver fibrosis index examination Blood sampling to check serum type III pre-collagen, laminin, hyaluronic acid, type IV collagen, etc., can initially determine the degree of liver fibrosis. 7, hepatitis B virological indicators, including hepatitis B virus “two to half”, hepatitis B virus DNA, etc., to understand the virus replication and infectious size. 8.Glucose, urine glucose, urine routine, etc. Mainly to understand whether there are hepatitis B-related diseases, such as hepatogenic diabetes mellitus, hepatitis B virus-related nephritis, etc. 9.Liver puncture examination When other means and testing methods cannot clarify the severity of the disease or if there is doubt, liver puncture can be performed to take biopsies to help confirm the diagnosis. In general, it is sufficient to routinely perform only the liver function series of tests. Only when there is a suspicion of serious conditions such as liver cirrhosis or liver cancer, more tests are needed.