Isoprinosine is effective in relieving vertigo in patients with otolithiasis, and other medications to improve microcirculation in the inner ear include betahistine and ginkgo biloba extract, etc. Medication is mainly symptomatic, so what medication is best varies from person to person. Otolithiasis is mostly treated by manipulation or instrumental repositioning. Otolithiasis is a common peripheral vestibular disease, the characteristic symptom is the appearance of positional vertigo, mostly in people over 40 years of age, otolithiasis medication individual differences, there is no best or the most effective medication that, more often than not, to take manipulation or instrumental repositioning method of treatment. Isoprinosine is usually considered to relieve the patient’s vertigo, and other medications such as betahistine and ginkgo biloba extract can be used as adjunctive therapy for dizziness after otolith repositioning. Other treatments include some vestibular rehabilitation such as the Brandt-Daroff method and balance training. The use of medication should be under the supervision of a doctor and should not be used without authorization.