All pain medications have to be used only when they are needed to relieve pain, and there are hazards in taking pain medications for a long time, as follows: 1. When the cause of the disease is not diagnosed, taking pain medications may mask the condition and delay treatment, so pain medications must be taken under the guidance and advice of a professional doctor, and the process of taking them must also be followed up on time and regularly; 2. Even if they are taken orally in a relatively mild route, there is also the risk of addiction; 3. There are many adverse effects on various organs of the body, such as the kidneys, stomach, digestive tract, as well as the cardiovascular and blood systems, such as long-term use may lead to gastrointestinal bleeding, gastric ulcers, and may also cause interstitial nephritis of the kidneys and affect the hematopoietic function of the blood system.