The drug treatment for gastric ulcer mainly includes acid suppression, protection of gastric mucosa, and eradication of H. pylori. The specific medications that work well will depend on the cause and condition of the patient. For the pharmacological treatment of gastric ulcer, the presence of H. pylori infection and the history of aspirin and non-steroidal anti-inflammatory drugs should be evaluated first. If H. pylori infection is present, strive to eradicate the bacteria to the greatest extent possible. The current regimen for H. pylori eradication is a quadruple regimen of 1 PPI + 2 antibiotics + 1 bismuth agent for 10-14 days. Commonly used PPIs (proton pump inhibitors) are omeprazole, lansoprazole, etc., antibiotics are amoxicillin, clarithromycin, metronidazole, etc., and bismuth is bismuth potassium citrate, etc. If taking aspirin or NSAIDs, discontinue them as much as possible if other conditions allow. If discontinuation is not possible, eradicate H. pylori as much as possible, because mucosal damage and ulcer development caused by aspirin or NSAIDs are significantly more likely to occur in the presence of H. pylori infection and less likely to occur if there is no bacterial infection. Of course, in patients with multiple coexisting diseases or discontinuation of aspirin, etc. may not be realistic, and in such cases a strong gastric acid inhibiting agent such as arazole is needed for continuous application, and a mucosal protective agent can be added together to maintain treatment for ulcer healing or to reduce the chance of serious complications such as bleeding and perforation. If the patient has abdominal pain, bloating, acid reflux and other symptoms, the principle of symptomatic treatment should be applied, with some lazoles, H2 receptor antagonists such as famotidine and ranitidine; mucosal protective agents (magnesium aluminocarbonate, gefalte, tiopresidone, etc.) for symptomatic treatment. Therefore, gastric ulcer drug therapy, although the principle is simple, the specific situation of the patient is different, and the selection and combination of drugs has a certain flexibility. It is necessary to develop an individualized plan according to the patient’s situation and to adhere to it for a long time so as to achieve the best results.