Blood creatinine 114.9 μmol/L suggests that blood creatinine is elevated, which is divided into physiological and pathological conditions. Physiologic cases are usually not serious; pathologic cases include acute kidney injury and chronic kidney disease. Elevated creatinine caused by acute kidney injury can be recovered after removing the causative factors and is usually not serious. Elevated creatinine caused by chronic kidney disease is more serious and usually difficult to recover. Physiological: after strenuous exercise or eating a high protein diet, blood creatinine may rise transiently, and may return to normal after resting or controlling the diet, which is usually not serious. Pathologic: including acute kidney injury and chronic kidney disease. Acute kidney injury is divided into pre-renal, renal and post-renal. Pre-renal, such as insufficient effective circulating blood volume, and post-renal, such as stones, etc., creatinine can mostly be restored after rehydration and removal of obstructive factors, and is usually not serious. Elevated blood creatinine caused by chronic kidney disease is more serious and usually difficult to recover, only to maintain and delay the progress of the disease, should be timely treatment of the primary disease, prevention and treatment of renal anemia, renal bone disease and other complications. Patients with blood creatinine 114.9μmol/L should go to the hospital in time to find out the cause and follow the doctor’s instructions to standardize the treatment, so as to avoid adverse consequences.