Mycoplasma and Chlamydia are microorganisms that are distinct from bacteria and viruses, and some types are pathogenic to humans, with some differences between them. From a biological point of view, the main difference between mycoplasma and chlamydia is that mycoplasma does not have a cell wall, while chlamydia has a cell wall, so drugs that inhibit cell wall production, such as penicillin, are not effective for mycoplasma infections, but can be used to treat chlamydia infections. There are five types of mycoplasma that can cause disease, including human mycoplasma and mycoplasma pneumoniae, which can lead to upper respiratory tract infections and urinary infections, while the commonly referred to chlamydia is Chlamydia trachomatis, which can lead to trachoma, parrot fever and urinary infections. There is a big difference in the biological structure of the two, and they are not the same two microorganisms, but there are many similarities in the diseases that can be induced by infection. In the treatment, there are some differences in the use of drugs, mycoplasma more tetracycline or macrolide drugs, chlamydia infection more antibiotic treatment. The main differences between mycoplasma and chlamydia lie in their biological makeup and the diseases they can induce, and there are also differences in the medications used to treat them.