Patients newly diagnosed with diabetes need to be treated with care to rule out the possibility of pancreatic cancer in combination. In recent years, numerous studies have shown a relationship between pancreatic cancer and diabetes mellitus. Patients with pancreatic cancer may not have any clinical manifestations in the early stage, or may show non-specific symptoms of the digestive or endocrine system. If typical manifestations such as jaundice and wasting occur, patients are almost always lost to surgical resection. Less than 10% of pancreatic cancer can be resected, and once diagnosed without surgery, 70% of patients have a survival period of no more than 6 months, and even if surgery is performed, the 5-year survival rate after surgery is <5%. Therefore, pancreatic cancer is the king of cancers. Early detection and treatment are very important to improve the prognosis. Recent studies have shown that the risk of pancreatic cancer in people with new onset diabetes (Q2 years of disease) is 4.43 times higher than that of patients without diabetes. Therefore, patients with new onset diabetes mellitus of Q2 year duration, especially those without family history of diabetes mellitus, should be screened for pancreatic cancer. The onset of pancreatic cancer-related diabetes mellitus is similar to type 2 diabetes mellitus, but it also has its own characteristics: 1) the age of onset is relatively large, often older than 60 years old, and it is more common in women; 2) there is no family history of diabetes mellitus; 3) there are no "three more" symptoms, but the weight loss is more obvious in a short period of time; 4) there is often abdominal pain or abdominal discomfort at the beginning of the disease; 5) there is a combination of hypertension and coronary heart disease. Combined hypertension and coronary heart disease, especially hyperlipidemia is relatively rare; 6. Tumor markers CA19-9 and CEA are often abnormal. Therefore, pancreatic ultrasound should be routinely performed in middle-aged and elderly type 2 diabetic patients with symptoms such as epigastric pain, low back pain and anorexia, and should be followed up closely.