Enlarged lymph nodes in the neck after total thyroidectomy may be caused by postoperative wound infection leading to inflammation or metastasis of cancer, which can be treated by medication, radiotherapy or surgery. 1. Wound infection: swollen lymph nodes after thyroid surgery may be related to wound infection. You can use anti-inflammatory drugs such as amoxicillin and penicillin under doctor’s guidance to improve the swelling of lymph nodes. 2. Cancer metastasis: Thyroid cancer metastasizes to the lymph nodes in the neck, and enlarged lymph nodes in the neck may also appear after total thyroidectomy. At this time, it is necessary to go to the hospital for X-ray examination in time to know the structure of lymph nodes, corticomedullary structure, and whether there is any localized lymph node metastasis. If there is local lymph node metastasis, iodine-131 radiotherapy can be used according to the doctor’s instruction, and lymph node removal surgery can be performed at the same time. If the lymph nodes in the neck are enlarged after total thyroidectomy, the patient should consult a doctor for examination, clarify the specific cause of the disease, and then follow the doctor’s instructions for treatment, so as to avoid delaying the condition.