Adults who receive the hepatitis B vaccine usually produce antibodies, and if they do not produce antibodies, it may be because they have not been detected for the time being or the vaccinated person is a carrier of the hepatitis B virus. Adults usually produce antibodies about one month after the first dose of hepatitis B vaccine, but antibody levels are usually not very high at this time, and the second and third doses of hepatitis B vaccine are needed later. The second and third doses are needed later. After the second and third doses, the antibody level is usually at its peak. However, antibody levels need to be rechecked regularly, and a booster shot should be given if the antibody level decreases. If antibodies are not produced after hepatitis B vaccination, it may be due to individual reasons that the antibody production time in the body is slow and not detected for the time being. Or there is hepatitis B virus in the patient’s body, especially mutated hepatitis B virus, which usually does not respond to hepatitis B vaccine. Adults who do not have hepatitis B antibodies in their bodies should go to regular hospitals as soon as possible for hepatitis B vaccination, which can reduce the risk of hepatitis B virus infection.