Appendiceal thickening is not only due to inflammatory changes of the appendix, but also in some patients due to tumors of the appendix, especially appendiceal carcinoid tumors. In contrast, appendicitis is a common surgical emergency abdominal condition that presents with right lower abdominal pain or typical metastatic right lower abdominal pain, related to the anatomical features of the appendix. It is associated with the anatomical features of the appendix. Secondary infection can occur due to obstruction and can also lead to thickening of the appendiceal duct wall and lymphatic follicular hyperplasia. Ultrasound or CT examination may reveal swelling of the appendix, thickening of the duct wall, or even significant changes of exudate around the duct lumen. For early diagnosis of appendicitis, the appendix should be surgically removed. In addition, lesions in the ileocecal region that compress the opening of the appendix may also lead to thickening of the appendiceal duct wall, which is also a non-specific manifestation of the tumor and needs to be addressed by surgical treatment.