Sudden and unexplained sore throat, common diseases include: acute pharyngitis, acute suppurative tonsillitis, acute epiglottitis, etc. Oral medication, topical tablets and mouthwash can be used for comprehensive treatment. At the same time, attention should be paid to avoid spicy and stimulating food, avoid smoking and alcohol, environmental pollution, such as good protection, to reduce the triggering factors. 1. Acute pharyngitis: Acute pharyngitis causes sore throat, generally consider medication, including: blue scutellaria oral solution, PuDiLan anti-inflammatory tablets, etc., but also can use compound furacilin gargle, dulcetylmethamphetamine tablets. 2. Acute purulent tonsillitis: penicillin can be used according to the severity of the patient’s condition, and gargles with antibacterial effect can also be used, such as compound chlorhexidine gargle, compound borax gargle, and so on. 3. Acute epiglottitis: If the root of epiglottis is compressed by inflammatory infiltration, so that venous return is blocked, the epiglottis will rapidly develop intense edema, and it is not easy to subside. Most patients have a sore throat that worsens when swallowing. Treatment requires the application of antibiotics (penicillin), glucocorticoids (dexamethasone multi, etc.), and incision and drainage of pus, as appropriate. Sudden and unexplained sore throat, it is recommended to actively go to the hospital for examination to clarify the cause of the disease, and then standardize the use of drugs and treatment.