Luteolin overdose hazards are mainly as follows: First, cause damage to the gastric mucosa, luteolin is acidic, such as long-term large amounts of taking will cause the gastric mucosa, gastrointestinal tract overload, will cause acid reflux, heartburn, in the long run will cause mild gastric mucosal discomfort or even cause mild gastric ulcers. The second point is that long-term large amounts of lutein can cause excessive burden on kidney function, and it is not recommended to take lutein for a long time when the compensatory function of the kidneys is diminished. The third point is that lutein and certain other drugs should not be taken at the same time, otherwise it is not only difficult to achieve the effect but may even cause some side damage to the body. It should not be used together with sulfonamide drugs, otherwise it will form kidney stones, and should not be taken together with aspirin and other drugs, which will reduce the effectiveness of the drug, and should not be taken at the same time with other B vitamins, which will destroy the effectiveness of vitamin B and lutein respectively by redox reactions.