Luteolin overdose hazards are mainly as follows: First, cause damage to the gastric mucosa, luteolin is acidic, such as long-term large amounts of taking will cause the gastric mucosa, gastrointestinal tract overload, causing acid reflux, heartburn, in the long run will cause mild gastric mucosal discomfort or even cause mild gastric ulcer. The second point is that taking lutein in large quantities for a long time will cause excessive burden on kidney function, and it is not recommended to take lutein for a long time when the compensatory function of the kidney is reduced. The third point, lutein and some other drugs can not be taken at the same time, otherwise it is not only difficult to achieve the effect may even cause some side damage to the body. Luteolin should not be used together with sulfonamide drugs, otherwise it will form kidney stones, should not be taken together with aspirin and other drugs, which will reduce the effectiveness of the drug, and can not be taken at the same time with other B vitamins, redox reactions will occur to destroy the effectiveness of B vitamins and luteolin.