Diarrhea, also known as diarrhea, can lead to exacerbation of kidney disease. There are many factors that can lead to the aggravation of kidney disease, and diarrhea is one of them. After diarrhea, when a large amount of water is discharged from the body, the effective blood volume will be insufficient, then the renal artery will be constricted, which will lead to insufficient perfusion of the kidney, and the kidney will be in a state of ischemia, and the kidney function damage will be aggravated. Therefore, in case of diarrhea, treatment needs to be actively given. In case of infectious diarrhea, anti-infection and rehydration treatment should be given; in case of non-infectious diarrhea, anti-diarrhea and rehydration treatment should be given, and the core of the above treatment is to maintain blood pressure and kidney perfusion. In addition, heavy sweating and vomiting can have the same effect as diarrhea, both of which can cause inadequate perfusion of the kidneys. Other factors that can lead to aggravation of kidney function include hypertension, infection, hypercalcemia, and certain nephrotoxic drugs, etc. All of these factors should be prevented or avoided in life.