Itchy testicles should be referred to as scrotal itching. Causes of scrotal itching are more, such as scrotal eczema, atopic dermatitis, neurodermatitis, scrotal inflammation, and fungal infections, etc. The drugs needed for different causes are not the same, and the more common ones are antihistamines such as cetirizine, glucocorticosteroids such as tretinoin, and antifungal drugs such as ketoconazole cream. 1. Scrotal eczema: you can use related glucocorticoid drugs such as tretinoin ointment externally. When there is oozing can be given boric acid liquid cleaning, accompanied by skin infection, local can also be given erythromycin ointment and other antibacterial drugs. 2. Allergic dermatitis: medication needs to be used on the basis of detachment from allergens, antihistamines can be taken, such as cetirizine, etc., and glucocorticoid drugs can be used if necessary, such as prednisone. 3. Neurodermatitis: mainly given antihistamines such as loratadine treatment, but also can be given calcium gluconate and other calcium treatment, if necessary, can be given to prednisone and other hormone drugs. 4. Scrotal inflammation: mainly due to vitamin B2 deficiency, in addition to the use of antihistamines and glucocorticoid hormone drugs, but also need to supplement vitamin B2. 5. Fungal infections: need to give the relevant antifungal drug treatment, such as ketoconazole cream, miconazole nitrate cream and so on. It is recommended that patients go to the hospital, improve the auxiliary examination, in order to clarify the cause of the disease, the drug needs to be used under the guidance of a professional physician.