The reasons for the symptoms of swollen hands and feet after waking up are as follows: 1, caused by excessive drinking at night while sleeping; 2, caused by malnutrition, such as the patient is usually malnourished, or suffering from gastrointestinal diseases, causing digestive malabsorption, which may lead to hypoproteinemia, and the patient may have symptoms of swollen hands and feet after waking up; 3, heart disease, such as rheumatic heart disease, coronary artery atherosclerosis heart disease, etc., there may be manifestations of heart failure. Due to diastolic insufficiency of the heart, patients may have generalized swelling; 4. Chronic kidney disease, due to water and sodium retention may also show symptoms of swollen hands and feet; 5. Cirrhosis of the liver, hypoproteinemia may occur, and patients may also have swollen hands and feet and may have severe ascites. Therefore, in this case, further examination is needed to clarify the cause of the disease and to provide targeted treatment according to the cause.