Whether at work or in the clinic, we can easily find that female patients or aunts and uncles around us after menopause more or less appear to be unable to remember recent events, in many simple things will be “confused”, some serious people will be completely unable to remember their loved ones, but decades ago things are still fresh in their minds. What the hell is this? In fact, this is one of the common post-menopausal “sequelae” of women – menopause-related Alzheimer’s disease (AD), which is also commonly known as “dementia”. Why is Alzheimer’s disease (AD) easy to develop after menopause? ”Alzheimer’s disease is a progressive and fatal neurodegenerative disease that is characterized by deteriorating cognitive and memory functions, aphasia, loss of use, loss of recognition and other executive impairments, as well as mental and behavioral abnormalities and diminished functioning in life. In patients with Alzheimer’s disease, brain pathology is characterized by reduced brain weight and volume, massive neuronal death and loss in the frontoparietal and temporal cortices, and amyloid (Aβ) deposition. Biochemical changes include reduced levels of acetylcholine (closely related to memory), norepinephrine (related to emotion), and 5-hydroxytryptamine and its metabolites (related to the maintenance of normal mental function). Related studies have shown that estrogen has a significant protective and nutritional effect on neurons in the female brain, inhibiting the elevation of reactive oxygen radicals such as superoxide anion in brain tissue during cerebral ischemia and reducing apoptosis of healthy neurons. In addition, estrogen also has anti-brain amyloid deposits, dilates blood vessels and promotes the synthesis of various neurotransmitters, actively protecting women’s brains from “dementia”. After menopause, women may experience mental and physical symptoms that affect their quality of life and that of their families, as their estrogen levels decrease and this “umbrella” is gone. Can some estrogen delay the symptoms associated with dementia? Since estrogen is not available, can we supplement estrogen to slow down the onset of dementia? Theoretically, it seems that estrogen replacement therapy for menopausal patients (including those with artificial menopause after ovarian removal) should be effective in delaying the onset of Alzheimer’s disease. To this end, many epidemiological and clinical studies have been conducted by domestic and international professionals. Studies have shown that postmenopausal replacement therapy can delay the onset of Alzheimer’s disease or alleviate the somatic and psychiatric symptoms caused by the onset of Alzheimer’s disease, but of course, it is only applicable to people between the ages of 53 and 60, and there seems to be no significant effect at too old an age, which may be related to the gradual atrophy of female sexual organs and the decrease of pituitary function, so that estrogen cannot reach a certain level in the body and loses its basic protective effect. . It has also been found that whether estrogen replacement therapy improves the onset and symptoms of Alzheimer’s disease depends mainly on the timing and frequency of drug use, with prophylactic use before the onset of menopause being more effective, while use several years after menopause is not beneficial. Of course, further research is needed to determine whether hormone replacement therapy or prophylactic intervention for postmenopausal patients with Alzheimer’s disease increases the risk of breast cancer and endometrial cancer in women. We also expect that experts in the field will develop hormone replacement therapy drugs with clear efficacy and fewer complications. What should I do about post-menopausal Alzheimer’s disease? As mentioned earlier, there is no consensus on the use of estrogen replacement therapy for Alzheimer’s disease. So is there really nothing we can do for Alzheimer’s disease related to menopause? Should we just sit back and wait for death? For the prevention and treatment of the disease, it is necessary to let the patients themselves have a correct understanding of the disease, to do a good job of education, to accept the existence of old age, sickness and death as a norm; secondly, you can delay the time of brain weight and volume reduction by strengthening daily physical and mental work, and supplement some antioxidant foods such as grapes, nuts, carrots, spinach, oats, etc. can also delay the oxidation of brain-related tissue to a certain extent. The oxidation of nerve tissue, for the heavy physical and mental symptoms can take some anti-anxiety, improve sleep, vasodilator drugs; Finally, the simplest and most important point is that children must be psychologically supportive and understanding, understanding, often come home to see, accompany the elderly to enjoy the family, spend the last good days of life. Don’t say you don’t have time oh, one day we will all grow old, just grandmother than grandfather disease risk is higher, don’t because of today’s escape become tomorrow by others to escape the widowed elderly!