In the middle and late stage of colon cancer, it is necessary to do 12 times of chemotherapy, that is, half a year of chemotherapy, because the chemotherapy of colon cancer is done once every half a month, and 12 times is quite half a year, which is the current evidence of evidence-based medicine or the requirement of the guideline. The recommended program is to use combination chemotherapy program, such as capecitabine or 5-fluorouracil combined with oxaliplatin, which has good efficacy in the middle and late stage of colon cancer, so in the middle and late stage of colon cancer, it is necessary to do 12 times or half a year’s time of chemotherapy. 12 times in the middle of the time need to take a break or need to assess the efficacy of the treatment, specific reference to the treatment plan of each hospital or each doctor’s decision.