Treatment of renal colic 1, drug therapy renal colic is a common urological emergency, requiring emergency treatment, the application of drugs before paying attention to the careful identification with other acute abdominal disease. At present, there are more drugs to relieve renal colic, and each place can apply drugs flexibly according to their own conditions and experience. (1) non-steroidal analgesic and anti-inflammatory drugs: commonly used drugs such as diclofenac sodium (Fotalin) and indomethacin (anti-inflammatory pain), which can inhibit the biosynthesis of prostaglandins in the body and reduce the sensitivity of nociceptive nerve endings to pain-causing substances, and have a moderate analgesic effect. Diclofenac sodium is also able to reduce ureteral edema and decrease the rate of pain recurrence, commonly used as 50 mg, intramuscular injection. Diclofenac can also act directly on the ureter, and is administered as 25mg, orally, or as a diclofenac suppository 100mg, anally. Diclofenac sodium affects the glomerular filtration rate in patients with poor renal function, but has no effect on those with normal renal function. (2) Opioid analgesics: opioid receptor agonists, acting on the opioid receptors of the central nervous system, can relieve pain sensation, with strong analgesic and sedative effects, commonly used drugs are dihydromorphone (5-10mg, intramuscular injection), pethidine (50-100mg, intramuscular injection), prednisone (50-100rng, intramuscular injection) and tramadol (100mg. intramuscular injection), etc. Opioids should not be used alone in the treatment of renal colic, but generally need to be used together with antispasmodic drugs such as atropine and 654-2. (3) Antispasmodics: ①M-type choline receptor blockers, commonly used drugs include atropine sulfate and 654-2, which can relax ureteral smooth muscle and relieve spasm. The usual dose is 20mg, intramuscular injection; ② Progesterone can inhibit the contraction of smooth muscle and relieve spasm, and has certain efficacy in pain relief and stone removal; ③ Calcium ion blocker, nifedipine 10mg orally or sublingually, has a certain effect on relieving renal colic; ④ α-blocker (tamsulosin), some recent clinical reports at home and abroad show that α-blockers are useful in relieving ureteral smooth muscle spasm, treatment. renal colic with certain effect. However, its exact efficacy remains to be more clinical observation. Treatment of the first episode of renal colic should be started with NSAIDs and switched to other drugs if the pain persists. Morphine and other opioids should be used in combination with antispasmodics such as atropine. Diclofenac sodium tablets or suppositories of 50 mg twice/d for 3 to 10 days may be given when the ureteral stones are expected to have the potential to pass on their own. In addition, acupuncture to stimulate Kidney Yu, Jingmen, Sanyinjiao or A-Yi points also has the effect of relieving spasm and pain. 2.Surgical treatment should be considered when the pain cannot be relieved by drugs or when the stone diameter is larger than 6mm. (1) Extracorporeal shock-wavelithotripsy (ESWL), which is used as an emergency treatment, can not only control renal colic, but also quickly relieve obstruction by lithotripsy. (2) Intraureteral stent placement can also be used in conjunction with ESWL treatment. (3)Transureteral lithotripsy for stone extraction. (4) Percutaneous nephrostomy for drainage, especially for cases of renal colic with stone obstruction combined with severe infection. During treatment, attention is paid to the presence of co-infection and oliguria caused by bilateral obstruction or isolated renal obstruction, and if these conditions occur, aggressive surgical treatment is needed to relieve the obstruction as soon as possible.