How long does it take to work depends on the severity of constipation, personal constitution and the dosage of the cork, usually about 10-30 minutes to take effect. The main component of the corking gel is glycerin, which has the effect of laxative, mainly used to treat constipation. It is mainly used for the treatment of constipation. When using it, squeeze it into the anus and keep it there for a few minutes, so that the drug can mix with the stool and soften it, thus allowing it to be discharged smoothly. However, there are some patients who do not have any effect with the use of open plug, and need to use other medications, such as oral lactulose or drug enemas. You should try to eat more easily digestible food, more vegetables, fruits and other foods rich in dietary fiber, less spicy and stimulating food, and also pay attention not to overeat and overeat to minimize the probability of constipation.