After liver transplantation, metastasis to the lungs usually has no indication for surgery. It usually belongs to middle and advanced liver cancer, the condition is more serious, there are multiple metastases in the lungs, and the patient’s physical condition is poorer, so there is no role for surgical treatment, and it can be treated by targeted therapy, radiotherapy and chemotherapy to prolong the survival period. Hepatocellular carcinoma can be treated by targeted therapy, radiotherapy and chemotherapy to treat the lesions in the liver and lungs, promote tumor reduction and prolong the survival of patients. Targeted drugs include sorafenib, lenvatinib and so on, and chemotherapy drugs include cisplatin, fluorouracil and so on. Active treatment under the guidance of the doctor to alleviate the symptoms of the disease and prolong the survival period, maintain a regular diet, avoid exertion, appropriate exercise, and develop good living habits and dietary habits.